Mechanochemical activation with cyclodextrins followed by compaction as an effective approach to improving dissolution of rutin
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چکیده
منابع مشابه
Efficient mechanochemical synthesis of regioselective persubstituted cyclodextrins
A number of per-6-substituted cyclodextrin derivative syntheses have been effectively carried out in a planetary ball mill under solvent-free conditions. The preparation of Bridion® and important per-6-amino/thiocyclodextrin intermediates without polar aprotic solvents, a source of byproducts and persistent impurities, could be performed. Isolation and purification processes could also be simpl...
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Background. UVA irradiation is one of the most ubiquitous and penetrating environmental stress factor to human skin and it is crucially involved in various forms of skin damages including the photoaging and development of cancer. Mentioned skin damages are connected mainly with imbalance in redox status and consequently with cellular metabolic disturbances including changes in phospholipid medi...
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Easy access to modified cyclodextrins by an intramolecular radical approach.
A simple method to modify the primary face of cyclodextrins (CDs) is described. The 6(I)-O-yl radical of α-, β-, and γ-CDs regioselectively abstracts the H5(II), located in the adjacent D-glucose unit, by an intramolecular 1,8-hydrogen-atom-transfer reaction through a geometrically restricted nine-membered transition state to give a stable 1,3,5-trioxocane ring. The reaction has been extended t...
متن کاملSludge Dewatering with Cyclodextrins: a New Cost-effective Approach
Polymers are typically added to flocculate sludge during wastewater treatment. We have found that cyclodextrins (CDs) boost the performance of these polymers by increasing the cake solids and drainage rates of beltor screw-pressed biological or primary sludge. These benefits are obtained at very low CD dosage. CDs also decrease the specific resistance to filtration and increase the capture rate...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2020
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2020.119294